Randomise and treat urgently

Watch By James Heilman - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=57633908

Remember: Every minute counts

Watch By Garry Knight (Flickr: 4:06 PM) [CC BY-SA 2.0 (https://creativecommons.org/licenses/by-sa/2.0)], via Wikimedia Commonss

Traumatic Brain Injury
is a global problem

Watch By Sgt. Bryan Peterson - https://www.dvidshub.net/image/1008631, Public Domain, https://commons.wikimedia.org/w/index.php?curid=39650584

The CRASH-3 trial is a
step towards progress

Watch Credit: David Gregory & Debbie Marshall

A global collaboration

Gallery Courtesy of The CTU

Subscribe to receive the results

Subscribe Josh Estey/AusAID [CC BY 2.0 (https://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons

The trial in numbers

finish 11801 patients randomised

348 patients randomised in the Golden hour in 2018

finish 1199 Patients to recruit by 31 January 2019


Every minute counts
Watch our videos and find out why we need to randomise and treat early


Trial Updates
The latest news updates from our collaborating sites


Trial News
The latest newsletters from the Clinical Trials Unit


Receive the trial results
Register your interest in the trial and subscribe to our mailing list to receive notification of the trial results and updates.



    14th October 2016   Click here for: CRASH-3 Trial [Generic] Protocol Version 2 Click here for: CRASH-3 Trial Protocol Amendment Summary Recruitment continues until we have 10,000 patients randomised within 3 hours of injury....

  • Our final big challenge

    February 28th 2018   FURTHER REDUCE TIME TO TREATMENT AND INCREASE RECRUITMENT WITHIN THE LIFE-SAVING GOLDEN HOUR JANUARY 2018: The Independent Data Monitoring Committee reviewed the unblinded data for 10,000 patients and... They congratulate the global collaborators from all 29...



11,607 patients recruited

28 recruiting countries.

171 hospitals and medical centres.


The CRASH3 trial aims to provide the research based information to prevent death by Traumatic Brain Injury.

The CRASH3 trial is testing whether tranexamic acid, a blood clot stabiliser that was discovered in Japan in the 1950’s, can become an essential tool for fighting excessive bleeding in the brain after Traumatic Brain Injury.

more info


If you were a patient randomised into this trial and would like further information about your treatment, click below.

The staff at the hospital where you were being treated for your traumatic brain injury should have given you an information leaflet about the CRASH3 trial. If you have any questions or concerns about your treatment in the hospital, please contact your doctor in the first instance.

more info