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The CRASH-3 trial is being conducted to assess the effect of tranexamic acid on risk of death or disability in patients with Traumatic Brain Injury (TBI).  TBI can cause bleeding in the brain. If left to continue, it can create pressure that can lead to further damage that will result in death or permanent disability. By conducting this trial we are collecting important evidence to help determine if tranexamic acid is an effective treatment for patients with TBI. 

The CRASH-3 trial is inspired by the results of the CRASH-2 trial. The CRASH-2 trial showed that tranexamic acid, an affordable and heat stable drug, reduced death due to bleeding and had the most beneficial effect when administered as soon as possible after injury. 

3915 patients randomised 
(last updated 24/04/2015)

  • Earlier this year, Liz (CRASH-3 assistant trial manager), Haleema and Ian the Clinical Trials Unit directors visited collaborating hospitals in Malaysia.

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  • Congratulations to the following teams who have recently started recruiting patients: Services Hospital Lahore Pakistan, Royal Stoke University Hospital UK, Lahore General Hospital Unit II Pakistan, Hospital Tengu Ampuan Afzan Malaysia

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  • Highest Recruiters: High Technology Medical Center University Clinic Georgia, Royal London Hospital UK, Queen Elizabeth Hospital Birmingham UK, University Hospital Coventry UK

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